Abstract
5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small molecule compound studied as a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular metabolism and NAD+ regulation. NNMT catalyzes the methylation of nicotinamide, affecting the availability of this NAD+ precursor.
Molecular Background
- Chemical Name: 5-Amino-1-methylquinolinium
- Molecular Formula: C10H11N2+
- Molecular Weight: 175.21 g/mol
- Target: Nicotinamide N-methyltransferase (NNMT)
Research Applications
5-Amino-1MQ has been investigated for:
- NNMT Inhibition Studies: Enzyme inhibition and metabolic effects
- NAD+ Metabolism: Cellular energy and NAD+ salvage pathway research
- Adipocyte Research: Fat cell metabolism and differentiation
- Muscle Regeneration: Satellite cell activation and myogenesis
NNMT and Metabolism
NNMT has emerged as a target of research interest due to its role in:
- Regulating cellular NAD+ levels through nicotinamide methylation
- Differential expression across tissue types
- Association with metabolic phenotypes in preclinical models
- Potential role in SAM (S-adenosylmethionine) metabolism
Preclinical Research
Studies have examined 5-Amino-1MQ in:
- Diet-induced obesity models
- Adipocyte differentiation assays
- Muscle regeneration and satellite cell research
- Metabolic rate and energy expenditure studies
Technical Specifications
- Purity: ≥99% (HPLC verified)
- Storage: Store at -20°C protected from light
- Solubility: Water soluble
Current Research Status
5-Amino-1MQ remains a research tool compound. While preclinical studies have shown interesting metabolic effects, the compound is still in early investigational stages with no clinical trials as of December 2025.