Abstract
Dihexa (N-hexanoyl-Tyr-Ile-(6)aminohexanoic amide) is a small peptide analog of angiotensin IV that has been studied for its effects on cognitive function and neuroplasticity through hepatocyte growth factor (HGF) system modulation.
Molecular Background
- Class: Angiotensin IV analog
- Target: HGF/c-Met receptor system
- Molecular Weight: Small peptide (modified dipeptide)
- Bioavailability: Oral activity reported in rodents
Research Applications
- Cognitive Studies: Learning and memory research
- Synaptogenesis: Synapse formation and plasticity
- Neurodegenerative Models: Disease model investigations
- HGF Signaling: Growth factor pathway research
Proposed Mechanisms
- c-Met Activation: HGF receptor signaling enhancement
- Spinogenesis: Dendritic spine formation
- BDNF Effects: Neurotrophic factor modulation
- Synaptic Plasticity: LTP enhancement in hippocampus
Preclinical Research
Studies have examined Dihexa in:
- Aged rodent cognitive models
- Scopolamine-induced amnesia models
- Hippocampal slice preparations
- Neuronal culture synaptogenesis assays
Technical Specifications
- Purity: ≥99% (HPLC verified)
- Storage: Store at -20°C
Current Research Status
Dihexa has been studied primarily by academic research groups investigating cognitive enhancement mechanisms. No human clinical trials have been conducted as of December 2025. Long-term safety data is limited.