Abstract
Epithalon (also known as Epitalon or Epithalone) is a synthetic tetrapeptide based on the naturally occurring peptide Epithalamin, originally isolated from the pineal gland. It consists of four amino acids: Alanine-Glutamic acid-Aspartic acid-Glycine.
Molecular Background
- Sequence: Ala-Glu-Asp-Gly
- Molecular Formula: C14H22N4O9
- Molecular Weight: 390.35 g/mol
- Origin: Developed by Professor Vladimir Khavinson
Research Applications
- Telomerase Studies: Activation and telomere length research
- Pineal Function: Melatonin synthesis pathway studies
- Cellular Aging: Senescence marker investigations
- Circadian Research: Biological rhythm studies
Proposed Mechanisms
- Telomerase Activation: hTERT expression research
- Pineal Stimulation: Effects on melatonin production
- Gene Expression: Modulation of age-related genes
Preclinical Research
Studies have examined Epithalon in:
- Cell culture telomerase assays
- Rodent aging models
- Pineal function studies
- Combination protocols with other bioregulators
Technical Specifications
- Purity: ≥99% (HPLC verified)
- Storage: Store lyophilized at -20°C
Current Research Status
The majority of Epithalon research originates from the Khavinson laboratory. Independent replication by other research groups remains limited. No randomized clinical trials have been published in major indexed journals as of December 2025.