Abstract
SHLP2 (Small Humanin-Like Peptide 2) is a 26-amino-acid mitochondrial-derived peptide encoded in the same 16S rRNA region as Humanin. Discovered in 2014, it is part of the expanding family of mitochondrial-derived peptides (MDPs).
Molecular Background
- Length: 26 amino acids
- Sequence: MGVQPRTSRVRSGGRGAARW
- Origin: Mitochondrial 16S rRNA gene
- Circulating levels: 10-100 pM in human plasma
Research Applications
- Mitochondrial Function: Respiratory complex activity studies
- Metabolic Research: Insulin sensitivity investigations
- Longevity Studies: Correlation with aging phenotypes
- Exercise Physiology: Exercise-induced expression research
Comparison with Humanin
Research suggests SHLP2 may have:
- Higher receptor binding affinity
- Stronger effects on mitochondrial complex activity
- More robust correlation with longevity phenotypes
Preclinical Research
Studies have examined SHLP2 in:
- Long-lived animal models
- Metabolic disorder models
- Exercise intervention studies
- Mitochondrial function assays
Current Research Status
SHLP2 is a more recently discovered MDP compared to Humanin. Research is ongoing to characterize its mechanisms and therapeutic potential. No clinical trials exist as of December 2025.