Abstract
Thymosin Alpha-1 (TA1) is a 28 amino acid peptide originally isolated from the thymus gland. It was first identified from thymosin fraction 5 preparations and has been studied for its role in immune system modulation.
Molecular Background
- Length: 28 amino acids
- Molecular Formula: C129H215N33O55
- Molecular Weight: 3108.3 g/mol
- Modification: N-terminal acetylation
- Origin: Thymus gland extract
Research Applications
- T-Cell Studies: Maturation and activation research
- Dendritic Cell Research: Antigen presentation studies
- Cytokine Studies: Immune signaling pathway investigations
- Immunosenescence: Age-related immune decline research
- Vaccine Response: Immunogenicity studies
Proposed Mechanisms
- T-Cell Differentiation: Effects on T-cell subset development
- TLR Signaling: Toll-like receptor pathway modulation
- Cytokine Production: Effects on immune mediator release
- NK Cell Activity: Natural killer cell function research
Regulatory Status
Thymosin Alpha-1 has received regulatory approval in several countries for specific indications. It represents one of the more clinically advanced thymic peptides.
Technical Specifications
- Purity: ≥99% (HPLC verified)
- Storage: Store lyophilized at -20°C
Current Research Status
TA1 has an extensive research history and clinical use in some jurisdictions. It represents one of the better-characterized immune-modulating peptides available for research.